Alosetron

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Alosetron API Reference standards  and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com

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    Product Name : 4-Methyl-5-imidazolemethanol hydrochloride; 38585-62-5

    Code: JCAST-07
    CAS:  38585-62-5
    Chemical Formula: C5H9ClN2O
    Molecular Weight: 148.59
    Category: Reference Standards/API Drug Metabolites/Alosetron EP Impurities/Alosetron USP Impurities
    Literature: Ajay Kumar & Uday Maitra,SN Applied Sciences volume 2, Article number: 1973 (2020)
    Application: 4-Methyl-5-imidazolemethanol hydrochloride (CAS: 38585-62-5) useful as reference Impurity standard.
    4-Methyl-5-imidazolemethanol hydrochloride; 38585-62-5
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    Product Name : 6-hydroxy Alosetron HCl; 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazo1-4-yl)methyl]-1H-pyrido[4,3-b]-6-hydroxyindol-l-one, mono hydrochloride

    Code: JCAST-06
    CAS: NA
    Chemical Formula: C17H19ClN4O2
    Molecular Weight: 346.82
    Category: Reference Standards/API Drug Metabolites/Alosetron EP Impurities/Alosetron USP Impurities
    Literature: Camilleri, M., et al.: Lancet, 355, 1035 (2000), Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002), Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003), Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006), Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007)
    Application: 6-hydroxy Alosetron HCl: 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazo1-4-yl)methyl]-1H-pyrido[4,3-b]-6-hydroxyindol-l-one, mono hydrochloride useful as reference Impurity standard.
    6-hydroxy Alosetron HCl; 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazo1-4-yl)methyl]-1H-pyrido[4,3-b]-6-hydroxyindol-l-one, mono hydrochloride
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    Product Name : Alosetron Impurity D; 2,5-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

    Code: JCAST-05
    CAS: NA
    Chemical Formula: C13H14N2O
    Molecular Weight: 214.27
    Category: Reference Standards/API Drug Metabolites/Alosetron EP Impurities/Alosetron USP Impurities
    Literature: Organic and Biomolecular Chemistry, 2013, vol. 11, # 12, p. 1929 - 1932; Organic and Biomolecular Chemistry, 2013, vol. 11, # 12, p. 1929 - 1932
    Application: Alosetron Impurity D; 2,5-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one  useful as reference Impurity standard.
    Alosetron Impurity D; 2,5-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
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    Product Name : Alosetron Impurity C : 5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one

    Code: JCAST-04
    CAS: 122852-75-9
    Chemical Formula: C12H12N2O
    Molecular Weight: 200.24
    Category: Reference Standards/API Drug Metabolites/Alosetron EP Impurities/Alosetron USP Impurities
    Literature: US2010/113478, 2010, A1, Location in patent: Page/Page column 12; Organic Letters, 2017, vol. 19, # 17, p. 4600 - 4603; Organic Letters, 2016, vol. 18, # 11, p. 2556 - 2559;
    Application: Alosetron Hydrochloride Impurity C; 5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one (CAS: 122852-75-9) useful as reference Impurity standard.
    Alosetron Impurity C : 5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
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    Product Name : Alosetron Impurity B : 4-Methyl imidazole

    Code: JCAST-03
    CAS: 822-36-6
    Molecular Formula: C4H6N2
    Molecular Weight: 82.1
    Category: Reference Standards/API Drug Metabolites/Alosetron EP Impurities/Alosetron USP Impurities
    Literature: Bratulescu, George [Synthesis, 2009, # 14, art. no. Z02909SS, p. 2319 - 2320]; Gagliano, Ronald A.; Knowlton, Robert C.; Byers, Larry D.[Journal of Organic Chemistry, 1989, vol. 54, # 22, p. 5247 - 5250]
    Application: Alosetron Impurity B; 4-Methyl imidazole (CAS: 822-36-6) useful as reference Impurity standard.
    Alosetron Impurity B : 4-Methyl imidazole
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    Product Name : Alosetron Hydrochloride Impurity A : 4-methyl-1H-imidazol-5-yl)methanol hydrochloride

    Code: JCAST-02
    CAS: 38585-62-5
    Chemical Formula: C5H9ClN2O
    Molecular Weight: 148.59
    Category: Reference Standards/API Drug Metabolites/Alosetron EP Impurities/Alosetron USP Impurities
    Literature: SK&F Lab Co. US4063023, 1977, A;  Korea Institute of Science and Technology US4292431, 1981, A; Smith Kline & French Laboratories Limited US3984293, 1976, A
    Application: Alosetron Hydrochloride Impurity A; 4-hydroxymethyl-5-methylimidazole hydrochloride (CAS: 38585-62-5) useful as reference Impurity standard.
    Alosetron Hydrochloride Impurity A : 4-methyl-1H-imidazol-5-yl)methanol hydrochloride
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    Product Name : Alosetron Hydrochloride|2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazole-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, mono hydrochloride

    Code: JCAST-01
    CAS: 122852-42-0
    Molecular Formula: C17H19ClN4O
    Molecular Weight: 330.81
    Category: Reference Standards/API Drug Metabolites/Alosetron EP Impurities/Alosetron USP Impurities
    Literature: Camilleri, M., et al.: Lancet, 355, 1035 (2000), Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002), Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003), Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006), Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007)
    Application: Alosetron Hydrochloride; 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazole-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, mono hydrochloride (CAS:122852-42-0) is useful as reference standard. Medicinally it is a 5-HT3 antagonist
    Alosetron Hydrochloride|2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazole-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, mono hydrochloride
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