Sitagliptin
41 Results Found
Page 2 of 2
Sitagliptin is an orally available, competitive, beta-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DDP-4) with hypoglycemic activity. Sitagliptin may cause an increased risk in the development of pancreatitis. (Ref. NCI Thesaurus (NCIt) )
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other oral hypoglycemic agents. (Ref. LiverTox)
Sitagliptin is a triazolopyrazine that exhibits hypoglycemic activity. It has a role as a serine proteinase inhibitor, a hypoglycemic agent, an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor, an environmental contaminant and a xenobiotic. It is a triazolopyrazine and a trifluorobenzene. (Ref.Pub chem)
Sitagliptin API Reference standards and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require for any degradation Impurities contact info@drjcrbio.com, sales@drjcrbio.com
-
Free
Product Name : Sitagliptin Hydroxy Amide Impurity ;3-Hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Code: JCSIT-08 CAS: NA Chemical Formula:C16H14F6N4O2 Molecular Weight: 408.3 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Literature: Application: Sitagliptin Hydroxy Amide Impurity ;3-Hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-oneis useful as reference Impurity standard. ![Sitagliptin Hydroxy Amide Impurity ;3-Hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one](https://drjcrbio.com/wp-content/uploads/s-9.png)
-
Free
Product Name : Sitagliptin Ketoamide Impurity ; (2Z)-4-Oxo-4-[3-(trifluoroMethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one | 764667-65-4
Code: JCSIT-07 CAS: 764667-65-4 Chemical Formula: C16H12F6N4O2 Molecular Weight: 406.28 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Literature: Application:Sitagliptin Ketoamide Impurity ; (2Z)-4-Oxo-4-[3-(trifluoroMethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one | 764667-65-4 is useful as reference Impurity standard. ![Sitagliptin Ketoamide Impurity ; (2Z)-4-Oxo-4-[3-(trifluoroMethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one | 764667-65-4](https://drjcrbio.com/wp-content/uploads/s-10.png)
-
Free
Product Name : Sitagliptin N-Acetyl Impurity; N-Acetyl Sitagliptin; 7-[(3R)-3-[(N-Acetyl)amino]-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine (CAS: 1379666-94-0)
Code: JCSIT-06 CAS: 1379666-94-0 Chemical Formula: C18H17F6N5O2 Molecular Weight: 449.35 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Status: Limited Stock; Contact: sales@drjcrbio.com Application: Manufacturer of Sitagliptin N-Acetyl Impurity; N-Acetyl Sitagliptin; 7-[(3R)-3-[(N-Acetyl)amino]-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine (CAS: 1379666-94-0) is useful as reference Impurity standard. Note: The compounds strictly supplied only for R&D /AR&D purpose, not for human/animal consumption. ![Sitagliptin N-Acetyl Impurity; N-Acetyl Sitagliptin; 7-[(3R)-3-[(N-Acetyl)amino]-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine (CAS: 1379666-94-0)](https://drjcrbio.com/wp-content/uploads/s-11.png)
-
Free
Product Name : Sitagliptin Phosphate Hydrate; (R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate hydrate (CAS: 654671-77-9)
Code: JCSIT-05 CAS: 654671-77-9 Chemical Formula: C16H20F6N5O6P Molecular Weight: 523.32 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Status: Limited Stock ; Contact: sales@drjcrbio.com Application: Manufacturer of Sitagliptin Phosphate Hydrate; (R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate hydrate (CAS: 654671-77-9) is useful as reference Impurity standard. Note: The compounds strictly supplied only for R&D /AR&D purpose, not for human/animal consumption. ![Sitagliptin Phosphate Hydrate; (R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate hydrate (CAS: 654671-77-9)](https://drjcrbio.com/wp-content/uploads/s-12.png)
-
Free
Product Name : Sitagliptin Triazole Hydrochloride; 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (CAS: 762240-92-6)
Code: JCSIT-04 CAS: 762240-92-6 Chemical Formula: C6H8ClF3N4 Molecular Weight: 228.60 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Status: Limited Stock; Contact: sales@drjcrbio.com Application: Manufacturer of Sitagliptin Triazole Hydrochloride; 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (CAS: 762240-92-6) is useful as reference Impurity standard. Note: The compounds strictly supplied only for R&D /AR&D purpose, not for human/animal consumption. ![Sitagliptin Triazole Hydrochloride; 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (CAS: 762240-92-6)](https://drjcrbio.com/wp-content/uploads/s-13.png)
-
Free
Product Name : Sitagliptin 2-Desfluoro Impurity ;2-Desfluoro Sitagliptin ;(R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(4,5-difluorophenyl)butan-2-amine
Code: JCSIT-03 CAS: NA Chemical Formula: C16H16F5N5O Molecular Weight: 389.32 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Literature: Application: Sitagliptin 2-Desfluoro Impurity ;2-Desfluoro Sitagliptin ;(R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(4,5-difluorophenyl)butan-2-amine is useful as reference Impurity standard. ![Sitagliptin 2-Desfluoro Impurity ;2-Desfluoro Sitagliptin ;(R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(4,5-difluorophenyl)butan-2-amine](https://drjcrbio.com/wp-content/uploads/s-14.png)
-
Free
Product Name : Sitagliptin Desfluorobenzene Analog ;(R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylbutan-2-amine
Code: JCSIT-02 CAS: NA Chemical Formula: C16H18F3N5O Molecular Weight: 353.34 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Literature: Application:Sitagliptin Desfluorobenzene Analog ;(R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylbutan-2-amine is useful as reference Impurity standard. ![Sitagliptin Desfluorobenzene Analog ;(R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylbutan-2-amine](https://drjcrbio.com/wp-content/uploads/s-15.png)
-
Free
Product Name : Sitagliptin Enamine Impurity ; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine | 767340-03-4
Code: JCSIT-01 CAS: 767340-03-4 Chemical Formula: C16H13F6N5O Molecular Weight: 405.30 Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities Literature: Application:Sitagliptin Enamine Impurity ; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine | 767340-03-4 is useful as reference Impurity standard. ![Sitagliptin Enamine Impurity ; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine | 767340-03-4](https://drjcrbio.com/wp-content/uploads/s-16.png)
