Sacubitril

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Sacu bitril API Reference standards and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com

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    Product Name : ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester/149709-58-0

    Code: JCSAC-24
    CAS:149709-58-0
    Chemical Formula: C20H23NO3
    Molecular Weight: 325.40
    Category: Sacubitril Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester/149709-58-0 is useful as reference Impurity standard
    ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester/149709-58-0
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    Product Name : 4-Iodo-L-phenylalanine;24250-85-9

    Code: JCSAC-23
    CAS:24250-85-9
    Chemical Formula: C9H10INO2
    Molecular Weight: 291.09
    Category: Sacubitril Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  4-Iodo-L-phenylalanine;24250-85-9 is useful as reference Impurity standard
    4-Iodo-L-phenylalanine;24250-85-9
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    Product Name : (R)-2-(tert-butylamino)-3-(4-iodophenyl)propan-1-ol

    Code: JCSAC-22
    CAS:NA
    Chemical Formula: C13H20INO
    Molecular Weight: 333.21
    Category: Sacubitril Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  (R)-2-(tert-butylamino)-3-(4-iodophenyl)propan-1-ol;CAS;NA is useful as reference Impurity standard.
    (R)-2-(tert-butylamino)-3-(4-iodophenyl)propan-1-ol
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    Product Name : 4-Iodo-D-Phenylalanine; (R)-2-Amino-3-(4-iodophenyl)propanoic acid CAS: 62561-75-5

    Code: JCSAC-21
    CAS: 62561-75-5
    Chemical Formula: C9H10INO2
    Molecular Weight: 291.09
    Category: Sacubitril Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   4-Iodo-D-Phenylalanine; (R)-2-Amino-3-(4-iodophenyl)propanoic acid CAS: 62561-75-5 is useful as reference Impurity standard.
    4-Iodo-D-Phenylalanine; (R)-2-Amino-3-(4-iodophenyl)propanoic acid CAS: 62561-75-5
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    Product Name : Ethyl (2E,4S)-5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]- 2-methyl-2-pentenoate (ACI); 2131788-25-3

    Code: JCSAC-20
    CAS: 2131788-25-3
    Chemical Formula: C25H31NO4
    Molecular Weight: 409.52
    Category: Sacubitril Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   Ethyl (2E,4S)-5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]- 2-methyl-2-pentenoate (ACI); 2131788-25-3 is useful as reference Impurity standard.
    Ethyl (2E,4S)-5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]- 2-methyl-2-pentenoate (ACI); 2131788-25-3
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    Product Name : Methyl (2R)-2-(acetylamino)-3-(biphenyl-4-yl)propanoate ;164460-67-7

    Code: JCSAC-19
    CAS: 164460-67-7
    Chemical Formula: C18H19NO3
    Molecular Weight: 297.35
    Category: Sacubitril Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   Methyl (2R)-2-(acetylamino)-3-(biphenyl-4-yl)propanoate ;164460-67-7 is useful as reference Impurity standard.
    Methyl (2R)-2-(acetylamino)-3-(biphenyl-4-yl)propanoate ;164460-67-7
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    Product Name : Sacubitril maleic ester ; (E)-4-(((2S,4R)-1-([1,1′-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoic acid |

    Code: JCSAC-18
    CAS: NA
    Chemical Formula:C24H27NO5
    Molecular Weight:409.48
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   Sacubitril maleic ester | (E)-4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoic acid |is useful as reference Impurity standard.
    Sacubitril maleic ester ; (E)-4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoic acid |
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    Product Name : Sacubitril N-Acetyl impurity ; ethyl (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate

    Code: JCSAC-17
    CAS: N/A
    Chemical Formula:C22H27NO3
    Molecular Weight:353.46
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubitril N-Acetyl impurity ; ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate is useful as reference Impurity standard.
    Sacubitril N-Acetyl impurity ; ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
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    Product Name : Sacubitril N-boc acid Impurity; (2R,4S)-5-([1,1′-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid| 1012341-50-2

    Code: JCSAC-16
    CAS: 1012341-50-2
    Chemical Formula:C23H29NO4
    Molecular Weight:383.48
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   Sacubitril N-boc acid Impurity;(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid| 1012341-50-2 is useful as reference Impurity standard.
    Sacubitril N-boc acid Impurity; (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid| 1012341-50-2
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    Product Name : Sacubitril Isopropyl Ester Impurity

    Code: JCSAC-15
    CAS: NA
    Chemical Formula:C27H35NO5
    Molecular Weight:453.58
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubitril Isopropyl Ester Impurity is useful as reference Impurity standard.
    Sacubitril Isopropyl Ester Impurity
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    Product Name : Sacubitril Acid Impurity ;(2R, 4S)-5-([1, 1′-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid

    Code: JCSAC-14
    CAS: NA
    Chemical Formula:C22H25NO5
    Molecular Weight:383.44
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   Sacubitril Acid Impurity ;(2R, 4S)-5-([1, 1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acidis useful as reference Impurity standard.
    Sacubitril Acid Impurity ;(2R, 4S)-5-([1, 1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid
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    Product Name : Sacubitril (2R,4R)-Isomer/ Sacubitril 4-Epimer ;Sacubitril 4-Epimer;(2R,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester calcium salt|766480-48-2 (acid)

    Code: JCSAC-13
    CAS: 766480-48-2 (acid)
    Chemical Formula:C24H29NO5 (acid) ;  C24H28NO5. 1/2 Ca (calcium salt)
    Molecular Weight:411.49(acid) ;430.52 (calcium salt)
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   Sacubitril (2R,4R)-Isomer/ Sacubitril 4-Epimer ;Sacubitril 4-Epimer;(2R,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester calcium salt|766480-48-2 (acid) is useful as reference Impurity standard.
    Sacubitril (2R,4R)-Isomer/ Sacubitril 4-Epimer ;Sacubitril 4-Epimer;(2R,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester calcium salt|766480-48-2 (acid)
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    Product Name : Sacubitril Methyl ester;3-((1S,3R)-1-Biphenyl-4-ylmethyl-3-methoxycarbonyl-1-butylcarbamoyl) Propionic Acid; Sacubitril Methyl Ester |2408053-56-3

    Code: JCSAC-12
    CAS: 2408053-56-3
    Chemical Formula:C23H27NO5
    Molecular Weight:397.47
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubitril Methyl ester;3-((1S,3R)-1-Biphenyl-4-ylmethyl-3-methoxycarbonyl-1-butylcarbamoyl) Propionic Acid; Sacubitril Methyl Ester |2408053-56-3 is useful as reference Impurity standard.
    Sacubitril Methyl ester;3-((1S,3R)-1-Biphenyl-4-ylmethyl-3-methoxycarbonyl-1-butylcarbamoyl) Propionic Acid; Sacubitril Methyl Ester |2408053-56-3
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    Product Name : Sacubitril Pyrrolidinone Impurity ;(3R,5S)​-rel-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one (Racemic Mixture) |2101222-51-7

    Code: JCSAC-11
    CAS: 2101222-51-7
    Chemical Formula:C₁₈H₁₉NO
    Molecular Weight:265.35
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubitril Pyrrolidinone Impurity ;(3R,5S)​-rel-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one (Racemic Mixture) |2101222-51-7 is useful as reference Impurity standard.
    Sacubitril Pyrrolidinone Impurity ;(3R,5S)​-rel-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one (Racemic Mixture) |2101222-51-7
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    Product Name : Sacubutril impurity 9 ;Ethyl (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride; (2R,4S)-Ethyl 5-[(1,1′-biphenyl)-4-yl]-4-amino-2-methylpentanoate Hydrochloride |149690-12-0

    Code: JCSAC-10
    CAS: 149690-12-0
    Chemical Formula:C20H26ClNO2
    Molecular Weight:347.88
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubutril impurity 9 ;Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride; (2R,4S)-Ethyl 5-[(1,1'-biphenyl)-4-yl]-4-amino-2-methylpentanoate Hydrochloride |149690-12-0 is useful as reference Impurity standard.
    Sacubutril impurity 9 ;Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride; (2R,4S)-Ethyl 5-[(1,1'-biphenyl)-4-yl]-4-amino-2-methylpentanoate Hydrochloride |149690-12-0
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    Product Name : Sacubitril AHU-66 ;N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester |1426129-50-1

    Code: JCSAC-09
    CAS: 1426129-50-1
    Chemical Formula:C20H25NO3
    Molecular Weight:327.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:   Sacubitril AHU-66 ;N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester |1426129-50-1is useful as reference Impurity standard.
    Sacubitril AHU-66 ;N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester |1426129-50-1
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    Product Name : Sacubitril (3R,5S)-Pyrrolidinone Impurity / Cyclic impurity of sacubutril ;(3R,5S)-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one|1038924-70-7

    Code: JCSAC-08
    CAS: 1038924-70-7
    Chemical Formula: C18H19NO
    Molecular Weight: 265.35
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubitril (3R,5S)-Pyrrolidinone Impurity / Cyclic impurity of sacubutril ;(3R,5S)-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one|1038924-70-7 is useful as reference Impurity standard.
    Sacubitril (3R,5S)-Pyrrolidinone Impurity / Cyclic impurity of sacubutril ;(3R,5S)-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one|1038924-70-7
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    Product Name : Sacubutril impurity 11;(2R,4S)-5-([1,1′-Biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride |1038924-71-8

    Code: JCSAC-07
    CAS: 1038924-71-8
    Chemical Formula:C18H22ClNO2
    Molecular Weight: 319.83
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubutril impurity 11;(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride |1038924-71-8 is useful as reference Impurity standard.
    Sacubutril impurity 11;(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride |1038924-71-8
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    Product Name : Sacubitril Impurity E ; 2,5-Dioxopyrrolidine Sacubitril; (2R,4S)-5-(Biphenyl-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic Acid Ethyl Ester; 2,5-Dioxopyrrolidine Sacubitril; Sacubitril Impurity 2; |1038924-97-8

    Code: JCSAC-06
    CAS: 1038924-97-8
    Chemical Formula:C24H27NO4
    Molecular Weight:393.48
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sacubitril Impurity E ; 2,5-Dioxopyrrolidine Sacubitril; (2R,4S)-5-(Biphenyl-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic Acid Ethyl Ester; 2,5-Dioxopyrrolidine Sacubitril; Sacubitril Impurity 2; |1038924-97-8   is useful as reference Impurity standard.
    Sacubitril Impurity E ; 2,5-Dioxopyrrolidine Sacubitril; (2R,4S)-5-(Biphenyl-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic Acid Ethyl Ester; 2,5-Dioxopyrrolidine Sacubitril; Sacubitril Impurity 2; |1038924-97-8
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    Product Name : Sacubitril Impurity D ; Sacubitril N-Boc Ester; (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid Ethyl Ester |149709-60-4

    Code: JCSAC-05
    CAS: 149709-60-4
    Chemical Formula:C25H33NO4
    Molecular Weight:411.54
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubitril Impurity D ; Sacubitril N-Boc Ester; (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid Ethyl Ester |149709-60-4 is useful as reference Impurity standard.
    Sacubitril Impurity D ; Sacubitril N-Boc Ester; (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid Ethyl Ester |149709-60-4
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    Product Name : Sacubutril-(2R,4S) Isomer ; Sacubitril-(2R,4S) Isomer; 4-(((2R,4S)-1-([1,1′-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid |761373-05-1

    Code: JCSAC-04
    CAS: 761373-05-1
    Chemical Formula: C24H29NO5
    Molecular Weight:411.49
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubutril-(2R,4S) Isomer ; Sacubitril-(2R,4S) Isomer; 4-(((2R,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid |761373-05-1 C24H29NO5 411.49 is useful as reference Impurity standard.
    Sacubutril-(2R,4S) Isomer ; Sacubitril-(2R,4S) Isomer; 4-(((2R,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid |761373-05-1
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    Product Name : Sacubutril-(2R,4R) Isomer ; Sacubitril-(2R,4R) Isomer; 4-(((2R,4R)-1-([1,1′-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid |2259708-00-2

    Code: JCSAC-03
    CAS: 2259708-00-2
    Chemical Formula:C24H29NO5
    Molecular Weight:411.49
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubutril-(2R,4R) Isomer ; Sacubitril-(2R,4R) Isomer; 4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid |2259708-00-2 is useful as reference Impurity standard.
    Sacubutril-(2R,4R) Isomer ; Sacubitril-(2R,4R) Isomer; 4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid |2259708-00-2
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    Product Name : Sacubutril-(2S,4S) Isomer; (2S,4S)-Sacubitril; [S-(R*,R*)]-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1′-biphenyl]-4-pentanoic Acid Ethyl Ester; Sacubitril-(2S,4S) Isomer; 4-(((2S,4S)-1-([1,1′-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid; |149709-63-7

    Code: JCSAC-02
    CAS: 149709-63-7
    Chemical Formula:C24H29NO5
    Molecular Weight:411.49
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Sacubutril-(2S,4S) Isomer; (2S,4S)-Sacubitril; [S-(R*,R*)]-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester; Sacubitril-(2S,4S) Isomer; 4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid; |149709-63-7 is useful as reference Impurity standard.
    Sacubutril-(2S,4S) Isomer; (2S,4S)-Sacubitril; [S-(R*,R*)]-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester; Sacubitril-(2S,4S) Isomer; 4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid; |149709-63-7
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    Product Name : Sacubitril Desethyl Impurity ;Sacubitrilat ; Sacubitril Diacid ; (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ; 149709-44-4

    Code: JCSAC-01
    CAS: 149709-44-4
    Chemical Formula: C22H25NO5
    Molecular Weight: 383.44
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sacubitril Desethyl Impurity ;Sacubitrilat ; Sacubitril Diacid ; (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ; 149709-44-4  is useful as reference Impurity standard.
    Sacubitril Desethyl Impurity ;Sacubitrilat ; Sacubitril Diacid ; (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ; 149709-44-4
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