Dolutegravir

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Dolutegravir API Reference standards  and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com

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    Product Name : DRS-IIA; 5-Methoxy-6-(methoxycarbonyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-3-carboxylic acid

    Code: JCDLV-14
    CAS: NA
    Chemical Formula:C11H11NO7
    Molecular Weight: 269.21
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:DRS-IIA; 5-Methoxy-6-(methoxycarbonyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-3-carboxylic acid is useful as reference Impurity standard.
    DRS-IIA; 5-Methoxy-6-(methoxycarbonyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-3-carboxylic acid
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    Product Name : Dolutegravir;Sodium(4S,12aR)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12, 12a -hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-olate | 1051375-19-9

    Code: JCDLV-13
    CAS: 1051375-19-9
    Chemical Formula: C20H18F2N3NaO5
    Molecular Weight: 441.36
    Category: Reference Standards/Pharmaceutical/API Drug Impurities/Metabolites/EP/USP Impurities
    Literature:
    Application: Dolutegravir;Sodium(4S,12aR)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12, 12a -hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate | 1051375-19-9 is useful as reference Impurity standard.
    Dolutegravir;Sodium(4S,12aR)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12, 12a -hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate   |  1051375-19-9
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    Product Name : 2-Fluorobenzylamine | 89-99-6

    Code: JCDLV-12
    CAS: 89-99-6
    Chemical Formula: C7H8FN
    Molecular Weight: 125.15
    Category: Reference Standards/Pharmaceutical/API Drug Impurities/Metabolites/EP/USP Impurities
    Literature:
    Application: 2-Fluorobenzylamine | 89-99-6 is useful as reference Impurity standard.
    2-Fluorobenzylamine   |  89-99-6
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    Product Name : 4-Fluorobenzylamine | 140-75-0

    Code: JCDLV-11
    CAS: 140-75-0
    Chemical Formula: C7H8FN
    Molecular Weight: 125.15
    Category: Reference Standards/Pharmaceutical/API Drug Impurities/Metabolites/EP/USP Impurities
    Literature:
    Application: 4-Fluorobenzylamine | 140-75-0 is useful as reference Impurity standard.
    4-Fluorobenzylamine   |  140-75-0
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    Product Name : Dolutegravir Dimer Impurity;N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine | 1916490-96-4

    Code: JCDLV-10
    CAS: 1916490-96-4
    Chemical Formula: C14H9F4N
    Molecular Weight: 267.23
    Category: Reference Standards/Pharmaceutical/API Drug Impurities/Metabolites/EP/USP Impurities
    Literature:
    Application: Dolutegravir Dimer Impurity;N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine | 1916490-96-4 is useful as reference Impurity standard.
    Dolutegravir Dimer Impurity;N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine  |  1916490-96-4
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    Product Name : Dolutegravir S-Isomer;(S)-3-Aminobutan-1-ol | 61477-39-2

    Code: JCDLV-09
    CAS: 61477-39-2
    Chemical Formula: C4H11NO
    Molecular Weight: 89.14
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir S-Isomer;(S)-3-Aminobutan-1-ol | 61477-39-2 is useful as reference Impurity standard.
    Dolutegravir S-Isomer;(S)-3-Aminobutan-1-ol  |  61477-39-2
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    Product Name : DRS-II Hydroxy Impurity;(R)-2-(4-Hydroxybutan-2-yl)-9-methoxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid

    Code:JCDLV-08
    CAS: NA
    Chemical Formula: C14H16N2O6
    Molecular Weight: 308.29
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: DRS-II Hydroxy Impurity;(R)-2-(4-Hydroxybutan-2-yl)-9-methoxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid is useful as reference Impurity standard.
    DRS-II Hydroxy Impurity;(R)-2-(4-Hydroxybutan-2-yl)-9-methoxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid
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    Product Name : Dolutegravir Hydroxy Impurity; (R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide | 1973402-05-9

    Code: JCDLV-07
    CAS: 1973402-05-9
    Chemical Formula: C20H19F2N3O5
    Molecular Weight: 419.38
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir Hydroxy Impurity; (R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide | 1973402-05-9 is useful as reference Impurity standard.
    Dolutegravir Hydroxy Impurity; (R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide  |  1973402-05-9
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    Product Name : Dolutegravir O-Methyl Impurity ;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1335210-35-9

    Code: JCDLV-06
    CAS: 1335210-35-9
    Chemical Formula: C21H21F2N3O5
    Molecular Weight: 433.41
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir O-Methyl Impurity ;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1335210-35-9 is useful as reference Impurity standard.
    Dolutegravir O-Methyl Impurity ;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide  |  1335210-35-9
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    Product Name : Dolutegravir 2-Fluoro Impurity;Dolutegravir 4-Desfluoro Impurity; Sodium (4R)-9-((2-fluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-olate | 1863916-87-3

    Code: JCDLV-05
    CAS: 1863916-87-3
    Chemical Formula: C20H20FN3O5
    Molecular Weight: 401.39
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir 2-Fluoro Impurity;Dolutegravir 4-Desfluoro Impurity; Sodium (4R)-9-((2-fluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate | 1863916-87-3 is useful as reference Impurity standard.
    Dolutegravir 2-Fluoro Impurity;Dolutegravir 4-Desfluoro Impurity; Sodium (4R)-9-((2-fluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate  |  1863916-87-3
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    Product Name : Dolutegravir 2-Desfluoro Impurity ; Sodium (4R)-9-((4-fluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-olate | 1863916-88-4

    Code: JCDLV-04
    CAS: 1863916-88-4
    Chemical Formula: C20H20FN3O5
    Molecular Weight: 401.39
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir 2-Desfluoro Impurity ; Sodium (4R)-9-((4-fluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate | 1863916-88-4 is useful as reference Impurity standard.
    Dolutegravir 2-Desfluoro Impurity ; Sodium (4R)-9-((4-fluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate  |  1863916-88-4
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    Product Name : Dolutegravir Enantiomer ;Dolutegravir (S,R)-Isomer; Sodium (4S)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-olate; (4S,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1,2:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1309560-49-3

    Code: JCDLV-03
    CAS: 1309560-49-3
    Chemical Formula: C20H19F2N3O5
    Molecular Weight: 419.38
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir Enantiomer ;Dolutegravir (S,R)-Isomer; Sodium (4S)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate; (4S,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1,2:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1309560-49-3 is useful as reference Impurity standard.
    Dolutegravir Enantiomer ;Dolutegravir (S,R)-Isomer; Sodium (4S)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate; (4S,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1,2:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide  |  1309560-49-3
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    Product Name : Dolutegravir 4-Epimer; 4-epi-Dolutegravir; Dolutegravir (S,S)-Isomer; (4S,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1357289-37-2

    Code: JCDLV-02
    CAS: 1357289-37-2
    Chemical Formula: C20H19F2N3O5
    Molecular Weight: 419.38
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir 4-Epimer; 4-epi-Dolutegravir; Dolutegravir (S,S)-Isomer; (4S,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1357289-37-2 is useful as reference Impurity standard.
    Dolutegravir 4-Epimer; 4-epi-Dolutegravir; Dolutegravir (S,S)-Isomer; (4S,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide   |  1357289-37-2
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    Product Name : Dolutegravir Isomer-2 Impurity;Dolutegravir (R,R)-Isomer ; (4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1357289-29-2

    Code: JCDLV-01
    CAS: 1357289-29-2
    Chemical Formula: C20H19F2N3O5
    Molecular Weight: 419.38
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Dolutegravir Isomer-2 Impurity;Dolutegravir (R,R)-Isomer ; (4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | 1357289-29-2 is useful as reference Impurity standard.
    Dolutegravir Isomer-2 Impurity;Dolutegravir (R,R)-Isomer ; (4R,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide  |  1357289-29-2