Acebutolol

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Acebutolol is an ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent and a sympathomimetic agent. It is a member of ethanolamines, a propanolamine, a secondary amino compound, an ether, a monocarboxylic acid amide and an aromatic amide. It is a conjugate base of an acebutolol(1+) (ref: Acebutolol API Reference standards and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com).

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    Product Name : Acebutolol nitroso Impurity ;Acebutolol nitroso Impurity; N-(3-acetyl-4-(2-hydroxy-3-(isopropyl(nitroso)amino)propoxy)phenyl)butyramide

    Code: JCABT-13
    CAS: NA
    Chemical Formula: C18H27N3O5
    Molecular Weight: 365.43
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol nitroso Impurity ;Acebutolol nitroso Impurity; N-(3-acetyl-4-(2-hydroxy-3-(isopropyl(nitroso)amino)propoxy)phenyl)butyramide  is useful as reference Impurity standard.
    Acebutolol nitroso Impurity ;Acebutolol nitroso Impurity;  N-(3-acetyl-4-(2-hydroxy-3-(isopropyl(nitroso)amino)propoxy)phenyl)butyramide
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    Product Name : Acebutolol Impurity 2; N-(4-(3-(N-ethyl-N-propylamino)-2-hydroxypropoxy)-3-acetylphenyl)butyramide

    Code: JCABT-12
    CAS: NA
    Chemical Formula: C20H32N2O4
    Molecular Weight: 364.49
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity 2; N-(4-(3-(N-ethyl-N-propylamino)-2-hydroxypropoxy)-3-acetylphenyl)butyramide is useful as reference Impurity standard.
    Acebutolol Impurity 2;  N-(4-(3-(N-ethyl-N-propylamino)-2-hydroxypropoxy)-3-acetylphenyl)butyramide
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    Product Name : Acebutolol EP Impurity H ;N,N[(2-Hydroxypropane-1,3-diyl)bis[oxy(3-acetyl-1,4-phenylene)]]dibutanamide | 1329613-31-1

    Code: JCABT-11
    CAS: 1329613-31-1
    Chemical Formula: C27H34N2O7
    Molecular Weight: 498.57
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol EP Impurity H ;N,N[(2-Hydroxypropane-1,3-diyl)bis[oxy(3-acetyl-1,4-phenylene)]]dibutanamide | 1329613-31-1 is useful as reference Impurity standard.
    Acebutolol EP Impurity H ;N,N[(2-Hydroxypropane-1,3-diyl)bis[oxy(3-acetyl-1,4-phenylene)]]dibutanamide  |  1329613-31-1
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    Product Name : Acebutolol EP Impurity G ; Acebutolol Dimer Impurity ; N,N′-[[(1-Methylethyl)imino]bis[(2-hydroxypropane-1,3-diyl)oxy(3-acetyl-1,4-phenylene)]]dibutanamide | 1330165-98-4

    Code: JCABT-10
    CAS: 1330165-98-4
    Chemical Formula: C33H47N3O8
    Molecular Weight: 613.74
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol EP Impurity G ; Acebutolol Dimer Impurity ; N,N′-[[(1-Methylethyl)imino]bis[(2-hydroxypropane-1,3-diyl)oxy(3-acetyl-1,4-phenylene)]]dibutanamide | 1330165-98-4 is useful as reference Impurity standard.
    Acebutolol EP Impurity G ; Acebutolol Dimer Impurity ; N,N′-[[(1-Methylethyl)imino]bis[(2-hydroxypropane-1,3-diyl)oxy(3-acetyl-1,4-phenylene)]]dibutanamide  |  1330165-98-4
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    Product Name : Acebutolol Impurity K ; 3-Deacetyl-3-Butanoyl Acebutolol Hydrochloride ; N-[3-Butanoyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] butanamide HCl | 57898-71-2

    Code: JCABT-09
    CAS: 57898-71-2
    Chemical Formula: C20H33ClN2O4
    Molecular Weight: 400.94
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity K ; 3-Deacetyl-3-Butanoyl Acebutolol Hydrochloride ; N-[3-Butanoyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] butanamide HCl | 57898-71-2 is useful as reference Impurity standard.
    Acebutolol Impurity K ; 3-Deacetyl-3-Butanoyl Acebutolol Hydrochloride ;  N-[3-Butanoyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] butanamide HCl   |  57898-71-2
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    Product Name : Acebutolol Impurity J ; N-[3-Acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] propanamide ; 57898-79-0

    Code: JCABT-08
    CAS: 57898-79-0
    Chemical Formula: C17H27ClN2O4
    Molecular Weight: 358.86
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity J ; N-[3-Acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] propanamide is useful as reference Impurity standard.
    Acebutolol Impurity J ; N-[3-Acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] propanamide ; 57898-79-0
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    Product Name : Acebutolol Impurity I ; Acebutolol USP RC I; rac N-Desisopropyl-N-ethyl Acebutolol; N-Desisopropyl-N-Ethyl Acebutolol HCl ; N-[3-Acetyl-4-[(2RS)-3-(ethylamino)-2-hydroxypropoxy]phenyl]butanamide hydrochloride | 441019-91-6

    Code: JCABT-07
    CAS: 441019-91-6
    Chemical Formula: C17H27ClN2O4
    Molecular Weight: 358.86
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity I ; N-Desisopropyl-N-Ethyl Acebutolol HCl ; N-[3-Acetyl-4-[(2RS)-3-(ethylamino)-2-hydroxypropoxy]phenyl]butanamide hydrochloride | 441019-91-6 is useful as reference Impurity standard.
    Acebutolol Impurity I ; Acebutolol USP RC I; rac N-Desisopropyl-N-ethyl Acebutolol; N-Desisopropyl-N-Ethyl Acebutolol HCl ;  N-[3-Acetyl-4-[(2RS)-3-(ethylamino)-2-hydroxypropoxy]phenyl]butanamide hydrochloride   |  441019-91-6
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    Product Name : Acebutolol Impurity F ; Acebutolol Diol ; N-[3-Acetyl-4-[(2RS)-2,3-dihydroxypropoxy] phenyl]butanamide | 96480-91-0

    Code: JCABT-06
    CAS: 96480-91-0
    Chemical Formula: C15H21NO5
    Molecular Weight: 295.33
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity F ; Acebutolol Diol ; N-[3-Acetyl-4-[(2RS)-2,3-dihydroxypropoxy] phenyl]butanamide | 96480-91-0 is useful as reference Impurity standard.
    Acebutolol Impurity F ; Acebutolol Diol ;  N-[3-Acetyl-4-[(2RS)-2,3-dihydroxypropoxy] phenyl]butanamide   |  96480-91-0
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    Product Name : Acebutolol Impurity E ; Acebutolol Desacetyl Impurity ; N-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide; N-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide Hydrochloride;

    Code: JCABT-05
    CAS:  1432053-72-9
    Chemical Formula: C16H27ClN2O3
    Molecular Weight: 330.85
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity E ; Acebutolol Desacetyl Impurity ; N-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide is useful as reference Impurity standard.
    Acebutolol Impurity E ; Acebutolol Desacetyl Impurity ;  N-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide; N-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide Hydrochloride;
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    Product Name : Acebutolol Impurity D ; rac N-Desbutyroyl Acebutolol; (+/-)-1-[5-Amino-2-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]ethanone; DL-1-(2-Acetyl-4-aminophenoxy)-3-isopropylaminopropan-2-ol; 57898-80-3

    Code: JCABT-04
    CAS: 57898-80-3
    Chemical Formula: C14H23ClN2O3
    Molecular Weight: 302.8
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity D ; 1-[5-Amino-2-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]ethanone | 57898-80-3 is useful as reference Impurity standard.
    Acebutolol Impurity D ; rac N-Desbutyroyl Acebutolol; (+/-)-1-[5-Amino-2-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]ethanone; DL-1-(2-Acetyl-4-aminophenoxy)-3-isopropylaminopropan-2-ol;  57898-80-3
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    Product Name : Acebutolol Impurity C ; N-(3-Acetyl-4-hydroxyphenyl)butanamide, Acebutolol Imp. C (EP), Acebutolol USP Related Compound A, Acebutolol USP RC A,Acebutolol Hydrochloride Imp. C (EP); 40188-45-2

    Code: JCABT-03
    CAS: 40188-45-2
    Chemical Formula: C12H15NO3
    Molecular Weight: 221.25
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity C ; N-(3-Acetyl-4-hydroxyphenyl)butanamide | 40188-45-2 is useful as reference Impurity standard.
    Acebutolol Impurity C ; N-(3-Acetyl-4-hydroxyphenyl)butanamide, Acebutolol Imp. C (EP), Acebutolol USP Related Compound A, Acebutolol USP RC A,Acebutolol Hydrochloride Imp. C (EP); 40188-45-2
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    Product Name : Acebutolol Impurity B ; Diacetolol ; N-[3-Acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] acetamide; DL-3′-Acetyl-4′-[2-hydroxy-3-(isopropylamino)propoxy]acetanilide; (±)-Diacetolol; Diacetolol; 1-(4-Acetamido-2-acetylphenoxy)-2-hydroxy-3-isopropylaminopropane; DL-1-(2-Acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane; Acetylacebutolol; Acebutolol USP RC B; 22568-64-5

    Code: JCABT-02
    CAS: 22568-64-5
    Chemical Formula: C16H25ClN2O4
    Molecular Weight: 344.83
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Acebutolol Impurity B ; Diacetolol ; N-[3-Acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] acetamide | 22568-64-5 is useful as reference Impurity standard.
    Acebutolol Impurity B ; Diacetolol ;  N-[3-Acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl) amino] propoxy] phenyl] acetamide; DL-3'-Acetyl-4'-[2-hydroxy-3-(isopropylamino)propoxy]acetanilide; (±)-Diacetolol; Diacetolol; 1-(4-Acetamido-2-acetylphenoxy)-2-hydroxy-3-isopropylaminopropane; DL-1-(2-Acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane; Acetylacebutolol;  Acebutolol USP RC B;  22568-64-5
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    Product Name : Acebutolol Impurity A; 3′-Acetyl-4′-(2,3-epoxypropoxy)-butyranilide | 28197-66-2

    Code: JCABT-01
    CAS:  28197-66-2
    Chemical Formula: C15H19NO4
    Molecular Weight: 277.32
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature: Andresen, B., et al.: Drug Metab. Disposition, 7, 360 (1979),
    Application: Acebutolol Impurity A; 3'-Acetyl-4'-(2,3-epoxypropoxy)-butyranilide | 28197-66-2 is useful as reference Impurity standard.
    Acebutolol Impurity A; 3'-Acetyl-4'-(2,3-epoxypropoxy)-butyranilide  |  28197-66-2