Sildenafil

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Sildenafil API Reference standards and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com

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    Product Name : SILDENAFIL NITROAMIDE IMPURITY A ;1-Methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide;139756-01-8

    Code: JCSDF-22
    CAS: 139756-01-7
    Chemical Formula: C8H12N4O3
    Molecular Weight: 212.21
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: SILDENAFIL NITROAMIDE IMPURITY A ;1-Methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide;139756-01-8is useful as reference Impurity standard.
    SILDENAFIL NITROAMIDE IMPURITY A ;1-Methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide;139756-01-8
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    Product Name : SULPHONYL METHYL ESTER ;methyl 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonate | 2512206-40-3

    Code: JCSDF-21
    CAS: 2512206-40-3
    Chemical Formula: C18H22N4O5S
    Molecular Weight: 406.46
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: SULPHONYL METHYL ESTER ;methyl 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonate | 2512206-40-3  is useful as reference Impurity standard.
    SULPHONYL METHYL ESTER ;methyl 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonate  | 2512206-40-3
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    Product Name : Sildenafil N-Desmethyl Thione Impurity ;  Desmethyl Thiosildenafil ; 5-[2-Ethoxy-5-(1-piperazinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl- 7H-pyrazolo[4,3-d]pyrimidine-7-thione | 479073-86-4 

    Code:JCSDF-20
    CAS: 479073-86-4
    Chemical Formula: C21H28N6O3S2
    Molecular Weight: 476.62
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil N-Desmethyl Thione Impurity ;  Desmethyl Thiosildenafil ; 5-[2-Ethoxy-5-(1-piperazinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl- 7H-pyrazolo[4,3-d]pyrimidine-7-thione | 479073-86-4 is useful as reference Impurity standard.
    Sildenafil N-Desmethyl Thione Impurity ;  Desmethyl Thiosildenafil ; 5-[2-Ethoxy-5-(1-piperazinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl- 7H-pyrazolo[4,3-d]pyrimidine-7-thione | 479073-86-4 
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    Product Name : Sildenafil N-Desmethyl Metabolite ;N-Desmethyl Sildenafil ; 5-[2-Ethoxy-5-(piperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one |  139755-82-1 

    Code:JCSDF-19
    CAS: 139755-82-1
    Chemical Formula: C21H28N6O4S
    Molecular Weight: 460.55
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil N-Desmethyl Metabolite ;N-Desmethyl Sildenafil ; 5-[2-Ethoxy-5-(piperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one |  139755-82-1 is useful as reference Impurity standard.
    Sildenafil N-Desmethyl Metabolite ;N-Desmethyl Sildenafil ; 5-[2-Ethoxy-5-(piperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one |  139755-82-1 
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    Product Name : Sildenafil Lactam Impurity ;  5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one | 139756-21-1

    Code: JCSDF-18
    CAS: 139756-21-1
    Chemical Formula: C17H20N4O2
    Molecular Weight: 312.37
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Lactam Impurity ;  5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one | 139756-21-1 is useful as reference Impurity standard.
    Sildenafil Lactam Impurity ;  5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one | 139756-21-1
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    Product Name : Sildenafil Isobutylpyrazolopyrimidine Impurity ; 3-(2-Methylpropyl)-1H-pyrazolo[4,3-d]pyrimidine | 1346600-82-5

    Code: JCSDF-17
    CAS: 1346600-82-5
    Chemical Formula: C9H12N4
    Molecular Weight: 176.22
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Isobutylpyrazolopyrimidine Impurity ; 3-(2-Methylpropyl)-1H-pyrazolo[4,3-d]pyrimidine | 1346600-82-5 is useful as reference Impurity standard.
    Sildenafil Isobutylpyrazolopyrimidine Impurity ; 3-(2-Methylpropyl)-1H-pyrazolo[4,3-d]pyrimidine | 1346600-82-5
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    Product Name : Sildenafil EP Impurity D ;Desmethylpiperazinyl Sildenafil Sulfonic Acid ; 3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonic acid | 1357931-55-5 

    Code: JCSDF-16
    CAS: 1357931-55-5
    Chemical Formula: C17H20N4O5S
    Molecular Weight: 392.43
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil EP Impurity D ;Desmethylpiperazinyl Sildenafil Sulfonic Acid ; 3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonic acid | 1357931-55-5 is useful as reference Impurity standard.
    Sildenafil EP Impurity D ;Desmethylpiperazinyl Sildenafil Sulfonic Acid ; 3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonic acid | 1357931-55-5 
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    Product Name : Sildenafil EP Impurity C ; O-Desethyl Sildenafil ; 5-[2-Hydroxy-5-(4-methylpiperazinylsulphonyl)phenyl]1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyramidin-7-one | 139755-91-2 

    Code: JCSDF-15
    CAS: 139755-91-2
    Chemical Formula: C20H26N6O4S
    Molecular Weight: 446.52
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil EP Impurity C ; O-Desethyl Sildenafil ; 5-[2-Hydroxy-5-(4-methylpiperazinylsulphonyl)phenyl]1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyramidin-7-one | 139755-91-2 is useful as reference Impurity standard.
    Sildenafil EP Impurity C ; O-Desethyl Sildenafil ; 5-[2-Hydroxy-5-(4-methylpiperazinylsulphonyl)phenyl]1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyramidin-7-one | 139755-91-2 
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    Product Name : Sildenafil EP Impurity B ;Sildenafil N-Oxide ; 5-[2-Ethoxy-5-[(4-methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one | 1094598-75-0 

    Code: JCSDF-14
    CAS: 1094598-75-0
    Chemical Formula: C22H30N6O5S
    Molecular Weight: 490.58
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil EP Impurity B ;Sildenafil N-Oxide ; 5-[2-Ethoxy-5-[(4-methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one | 1094598-75-0 is useful as reference Impurity standard.
    Sildenafil EP Impurity B ;Sildenafil N-Oxide ; 5-[2-Ethoxy-5-[(4-methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one | 1094598-75-0 
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    Product Name : Sildenafil EP Impurity A ; Sildenafil USP RC A ; Sildenafil Isobutyl Analog ; 5-[2-Ethoxy-5-[(4-methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-(2-methylpropyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one

    Code: JCSDF-13
    CAS: 1391053-95-4
    Chemical Formula:  C23H32N6O4S
    Molecular Weight:488.6
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil EP Impurity A ; Sildenafil USP RC A ; Sildenafil Isobutyl Analog ; 5-[2-Ethoxy-5-[(4-methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-(2-methylpropyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one is useful as reference Impurity standard.
    Sildenafil EP Impurity A ; Sildenafil USP RC A ; Sildenafil Isobutyl Analog ; 5-[2-Ethoxy-5-[(4-methyl-4-oxido-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-(2-methylpropyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one
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    Product Name : Sildenafil Disulfonamide Dimer Impurity ;5-{2 -Ethoxy-5-[(4-{[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5yl) phenyl]sulfonyl}piperazino)sulfonyl]phenyl}-1-methyl-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-7–one | 1346602-67-2

    Code: JCSDF-12
    CAS: 1346602-67-2
    Chemical Formula: C38H46N10O8S2
    Molecular Weight: 834.96
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Disulfonamide Dimer Impurity ;5-{2 -Ethoxy-5-[(4-{[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5yl) phenyl]sulfonyl}piperazino)sulfonyl]phenyl}-1-methyl-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-7–one | 1346602-67-2 is useful as reference Impurity standard.
    Sildenafil Disulfonamide Dimer Impurity ;5-{2 -Ethoxy-5-[(4-{[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5yl) phenyl]sulfonyl}piperazino)sulfonyl]phenyl}-1-methyl-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-7–one  |  1346602-67-2
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    Product Name : Sildenafil Di-Amide Impurity ; 4-(2-Ethoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide| 139756-03-9

    Code: JCSDF-11
    CAS: 139756-03-9
    Chemical Formula: C17H22N4O3
    Molecular Weight: 330.38
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Sildenafil Di-Amide Impurity ; 4-(2-Ethoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide| 139756-03-9 is useful as reference Impurity standard.
    Sildenafil Di-Amide Impurity ; 4-(2-Ethoxybenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide| 139756-03-9
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    Product Name : Sildenafil Descarbon Impurity ; 3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(dimethylamino)ethyl]-4-ethoxy-benzenesulfonamide | 1393816-99-3 

    Code: JCSDF-10
    CAS: 1393816-99-3
    Chemical Formula: C21H30N6O4S
    Molecular Weight: 462.57
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Descarbon Impurity ; 3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(dimethylamino)ethyl]-4-ethoxy-benzenesulfonamide | 1393816-99-3 is useful as reference Impurity standard.
    Sildenafil Descarbon Impurity ; 3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(dimethylamino)ethyl]-4-ethoxy-benzenesulfonamide  | 1393816-99-3 
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    Product Name : Sildenafil Des(methylpiperazinyl) Chlorosulfone Impurity ; 4-Ethoxy-3-(7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl) benzene-1-sulfonyl chloride |  139756-31-3

    Code: JCSDF-09
    CAS: 139756-31-3
    Chemical Formula: C16H17ClN4O4S
    Molecular Weight: 396.85
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Des(methylpiperazinyl) Chlorosulfone Impurity ; 4-Ethoxy-3-(7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl) benzene-1-sulfonyl chloride |  139756-31-3 is useful as reference Impurity standard.
    Sildenafil Des(methylpiperazinyl) Chlorosulfone Impurity ; 4-Ethoxy-3-(7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl) benzene-1-sulfonyl chloride |  139756-31-3
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    Product Name : Sildenafil Chlorosulfone O-Desethyl Impurity ; 4-Hydroxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl)benzene-1-sulfonyl chloride | 139756-27-7

    Code: JCSDF-08
    CAS:139756-27-7
    Chemical Formula: C15H15ClN4O4S
    Molecular Weight: 382.82
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Chlorosulfone O-Desethyl Impurity ; 4-Hydroxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl)benzene-1-sulfonyl chloride | 139756-27-7 is useful as reference Impurity standard.
    Sildenafil Chlorosulfone O-Desethyl Impurity ; 4-Hydroxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl)benzene-1-sulfonyl chloride  | 139756-27-7
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    Product Name : Sildenafil Chlorosulfone Impurity ;Sildenafil Chlorosulfone ; Sildenafil Chlorosulfonyl Impurity ; 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-on |  139756-22-2

    Code: JCSDF-07
    CAS: 139756-22-2
    Chemical Formula: C17H19ClN4O4S
    Molecular Weight: 410.88
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Chlorosulfone Impurity ;Sildenafil Chlorosulfone ; Sildenafil Chlorosulfonyl Impurity ; 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-on |  139756-22-2 is useful as reference Impurity standard.
    Sildenafil Chlorosulfone Impurity ;Sildenafil Chlorosulfone ; Sildenafil Chlorosulfonyl Impurity ; 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-on |  139756-22-2
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    Product Name : Sildenafil Chlorosulfone 2-Methyl Isomer ; 4-Ethoxy-3-(2-methyl-7-oxo-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d] pyrimidin-5-yl)benzene-1-sulfonyl chloride |  501120-42-9

    Code: JCSDF-06
    CAS: 501120-42-9
    Chemical Formula: C17H19ClN4O4S
    Molecular Weight: 410.88
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Chlorosulfone 2-Methyl Isomer ; 4-Ethoxy-3-(2-methyl-7-oxo-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d] pyrimidin-5-yl)benzene-1-sulfonyl chloride |  501120-42-9 is useful as reference Impurity standard.
    Sildenafil Chlorosulfone 2-Methyl Isomer ; 4-Ethoxy-3-(2-methyl-7-oxo-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d] pyrimidin-5-yl)benzene-1-sulfonyl chloride |  501120-42-9
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    Product Name : Sildenafil Chloroacetyl Impurity ; 5-[5-(2-Chloroacetyl)-2-ethoxyphenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one | 1058653-74-9

    Code: JCSDF-05
    CAS: 1058653-74-9
    Chemical Formula: C19H21ClN4O3
    Molecular Weight: 388.85
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Chloroacetyl Impurity ; 5-[5-(2-Chloroacetyl)-2-ethoxyphenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one | 1058653-74-9 is useful as reference Impurity standard.
    Sildenafil Chloroacetyl Impurity ; 5-[5-(2-Chloroacetyl)-2-ethoxyphenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one | 1058653-74-9
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    Product Name : Sildenafil Carboxylic Acid Impurity ; 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl)benzoic acid |  147676-78-6 

    Code: JCSDF-04
    CAS: 147676-78-6
    Chemical Formula: C18H20N4O4
    Molecular Weight: 356.38
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Carboxylic Acid Impurity ; 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl)benzoic acid |  147676-78-6  is useful as reference Impurity standard.
    Sildenafil Carboxylic Acid Impurity ; 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d] pyrimidin-5-yl)benzoic acid |  147676-78-6 
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    Product Name : Sildenafil Amino Amide Impurity ; 4-Amino-1-methyl-3-propylpyrazole-5-carboxamide | 139756-02-8

    Code: JCSDF-03
    CAS: 139756-02-8
    Chemical Formula: C8H14N4O
    Molecular Weight: 182.22
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Amino Amide Impurity ; 4-Amino-1-methyl-3-propylpyrazole-5-carboxamide | 139756-02-8 is useful as reference Impurity standard.
    Sildenafil Amino Amide Impurity ; 4-Amino-1-methyl-3-propylpyrazole-5-carboxamide | 139756-02-8
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    Product Name : Sildenafil Aldehyde Impurity ; 2-Ethoxy-5-(4-methyl-piperazin-1-yl-sulphonyl)-benzaldehyde

    Code: JCSDF-02
    CAS: NA
    Chemical Formula: C14H20N2O4S
    Molecular Weight: 312.38
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil Aldehyde Impurity ; 2-Ethoxy-5-(4-methyl-piperazin-1-yl-sulphonyl)-benzaldehyde is useful as reference Impurity standard.
    Sildenafil Aldehyde Impurity ; 2-Ethoxy-5-(4-methyl-piperazin-1-yl-sulphonyl)-benzaldehyde
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    Product Name : Sildenafil 2-Ethoxybenzoyl Chloride Impurity ;  2-Ethoxybenzoyl chloride | 42926-52-3

    Code: JCSDF-01
    CAS: 42926-52-3
    Chemical Formula: C9H9ClO2
    Molecular Weight: 184.62
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Sildenafil 2-Ethoxybenzoyl Chloride Impurity ;  2-Ethoxybenzoyl chloride | 42926-52-3 is useful as reference Impurity standard.
    Sildenafil 2-Ethoxybenzoyl Chloride Impurity ;  2-Ethoxybenzoyl chloride | 42926-52-3