Irinotecan

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Irinotecan API Reference standards and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com

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    Product Name : SN38 Impurity C /86639-53-4

    Code:  JCIRN-17
    CAS: 86639-53-4
    Chemical Formula:C23H22N2O5
    Molecular Weight: 406.4
    Category: Irinotecan Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: SN38 Impurity C /86639-53-4 is useful as reference Impurity standard
    SN38 Impurity C /86639-53-4
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    Product Name : Camptothecin Impurity B/35364-15-9

    Code:  JCIRN-16
    CAS: 35364-15-9
    Chemical Formula: C9H11NO2
    Molecular Weight: 165.19
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Camptothecin Impurity B/35364-15-9 is useful as reference Impurity standard
    Camptothecin Impurity B/35364-15-9
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    Product Name : Irinotecan Acid Sodium Salt ;(S)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin acid sodium salt ;(αS)-2-[([1,4′-Bipiperidin]-1′-ylcarbonyl)oxy]-α,12-diethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic acid sodium salt | 1329502-92-2

    Code:  JCIRN-15
    CAS: 1329502-92-2
    Chemical Formula: C33H39N4NaO7
    Molecular Weight: 626.68
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan Acid Sodium Salt ;(S)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin acid sodium salt ;(αS)-2-[([1,4'-Bipiperidin]-1'-ylcarbonyl)oxy]-α,12-diethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic acid sodium salt | 1329502-92-2  is useful as reference Impurity standard
    Irinotecan Acid Sodium Salt ;(S)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin acid sodium salt ;(αS)-2-[([1,4'-Bipiperidin]-1'-ylcarbonyl)oxy]-α,12-diethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-indolizino[1,2-b]quinoline-7-acetic acid sodium salt  |  1329502-92-2
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    Product Name : Irinotecan EP Impurity A ;7-Desethyl Irinotecan (USP) ;Irinotecan USP Impurity A ; 11-Desethyl Irinotecan (EP) ;(S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4′-bipiperidine)-1′-carboxylate ;[1,4’-Bipiperidine]-1’-carboxylic acid (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl ester | 103816-16-6

    Code:  JCIRN-14
    CAS: 103816-16-6
    Chemical Formula: C31H34N4O6
    Molecular Weight: 558.62
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan EP Impurity A ;7-Desethyl Irinotecan (USP) ;Irinotecan USP Impurity A ; 11-Desethyl Irinotecan (EP) ;(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate ;[1,4’-Bipiperidine]-1’-carboxylic acid (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl ester | 103816-16-6  is useful as reference Impurity standard
    Irinotecan EP Impurity A ;7-Desethyl Irinotecan (USP) ;Irinotecan USP Impurity A ; 11-Desethyl Irinotecan (EP) ;(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate ;[1,4’-Bipiperidine]-1’-carboxylic acid (4S)-4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl ester  |  103816-16-6
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    Product Name : Irinotecan EP Impurity B ;Irinotecan USP RC A ;9-Hydroxy Camptothecin (EP) ;10-Hydroxy Camptothecin (USP) ;(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 19685-09-7

    Code: JCIRN-13
    CAS: 19685-09-7
    Chemical Formula: C20H16N2O5
    Molecular Weight: 364.35
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Irinotecan EP Impurity B ;Irinotecan USP RC A ;9-Hydroxy Camptothecin (EP) ;10-Hydroxy Camptothecin (USP) ;(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 19685-09-7  is useful as reference Impurity standard
    Irinotecan EP Impurity B ;Irinotecan USP RC A ;9-Hydroxy Camptothecin (EP) ;10-Hydroxy Camptothecin (USP) ;(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione  |   19685-09-7
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    Product Name : Irinotecan EP Impurity C ;11-Ethyl Irinotecan (USP) ;8-Ethyl Irinotecan (EP) ;(S)-4,8,11-Triethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4′-bipiperidine)-1′-carboxylate | 947687-02-7

    Code: JCIRN-12
    CAS: 947687-02-7
    Chemical Formula: C35H42N4O6
    Molecular Weight: 614.73
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Irinotecan EP Impurity C ;11-Ethyl Irinotecan (USP) ;8-Ethyl Irinotecan (EP) ;(S)-4,8,11-Triethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate | 947687-02-7  is useful as reference Impurity standard
    Irinotecan EP Impurity C ;11-Ethyl Irinotecan (USP) ;8-Ethyl Irinotecan (EP) ;(S)-4,8,11-Triethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-9-yl (1,4'-bipiperidine)-1'-carboxylate  |  947687-02-7
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    Product Name : Irinotecan EP Impurity D ;Topotecan USP RC C ;Camptothecin ;(S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione | 7689-03-4

    Code: JCIRN-11
    CAS: 7689-03-4
    Chemical Formula:  C20H16N2O4
    Molecular Weight: 348.35
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Irinotecan EP Impurity D ;Topotecan USP RC C ;Camptothecin ;(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione | 7689-03-4  is useful as reference Impurity standard
    Irinotecan EP Impurity D ;Topotecan USP RC C ;Camptothecin ;(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione  |  7689-03-4
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    Product Name : Irinotecan EP Impurity E ;Irinotecan USP RC B ;7-Ethyl-10-Hydroxy Camptothecin (USP) ; 11-Ethyl-9-Hydroxy Camptothecin (EP) ; (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7] indolizino[1,2-b] quinoline-3,14(4H,12H)-dione | 86639-52-3

    Code: JCIRN-10
    CAS:  86639-52-3
    Chemical Formula:  C22H20N2O5
    Molecular Weight: 392.40
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan EP Impurity E ;Irinotecan USP RC B ;7-Ethyl-10-Hydroxy Camptothecin (USP) ; 11-Ethyl-9-Hydroxy Camptothecin (EP) ; (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7] indolizino[1,2-b] quinoline-3,14(4H,12H)-dione | 86639-52-3 is useful as reference Impurity standard
    Irinotecan EP Impurity E ;Irinotecan USP RC B ;7-Ethyl-10-Hydroxy Camptothecin (USP) ; 11-Ethyl-9-Hydroxy Camptothecin (EP) ; (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7] indolizino[1,2-b] quinoline-3,14(4H,12H)-dione  |  86639-52-3
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    Product Name : Irinotecan EP Impurity F ;Irinotecan USP RC E ; 7-Ethyl Camptothecin (USP) ;11-Ethyl Camptothecin (EP) ;(S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 78287-27-1

    Code: JCIRN-09
    CAS:  78287-27-1
    Chemical Formula:  C22H20N2O4
    Molecular Weight: 376.41
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Irinotecan EP Impurity F ;Irinotecan USP RC E ; 7-Ethyl Camptothecin (USP) ;11-Ethyl Camptothecin (EP) ;(S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 78287-27-1  is useful as reference Impurity standard
    Irinotecan EP Impurity F ;Irinotecan USP RC E ; 7-Ethyl Camptothecin (USP) ;11-Ethyl Camptothecin (EP) ;(S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione  | 78287-27-1
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    Product Name : Irinotecan EP Impurity G ;Irinotecan USP Impurity G ;7,11-Diethyl-10-Hydroxy Camptothecin (USP) ;8,11-Diethyl-9-Hydroxy Camptothecin (EP) ;(S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b] quinoline-3,14(4H,12H)-dione | 947687-01-6

    Code: JCIRN-08
    CAS: 947687-01-6
    Chemical Formula: C24H24N2O5
    Molecular Weight: 420.46
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan EP Impurity G ;Irinotecan USP Impurity G ;7,11-Diethyl-10-Hydroxy Camptothecin (USP) ;8,11-Diethyl-9-Hydroxy Camptothecin (EP) ;(S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] quinoline-3,14(4H,12H)-dione | 947687-01-6  is useful as reference Impurity standard
    Irinotecan EP Impurity G ;Irinotecan USP Impurity G ;7,11-Diethyl-10-Hydroxy Camptothecin (USP) ;8,11-Diethyl-9-Hydroxy Camptothecin (EP) ;(S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] quinoline-3,14(4H,12H)-dione  |  947687-01-6
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    Product Name : Irinotecan EP Impurity H ;Irinotecan USP RC C ;4-Methyl Irinotecan Analog (EP) ;11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano [3′,4′:6,7]indolizino[1,2-b]quinoline-9-yl (1,4′-bipiperidine)- 1′-carboxylate hydrochloride

    Code: JCIRN-07
    CAS: NA
    Chemical Formula:  C32H37ClN4O6
    Molecular Weight: 609.11
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan EP Impurity H ;Irinotecan USP RC C ;4-Methyl Irinotecan Analog (EP) ;11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano [3',4':6,7]indolizino[1,2-b]quinoline-9-yl (1,4'-bipiperidine)- 1'-carboxylate hydrochloride   is useful as reference Impurity standard
    Irinotecan EP Impurity H ;Irinotecan USP RC C ;4-Methyl Irinotecan Analog (EP) ;11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano [3',4':6,7]indolizino[1,2-b]quinoline-9-yl (1,4'-bipiperidine)- 1'-carboxylate hydrochloride
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    Product Name : Irinotecan EP Impurity K ; (4S)-4-Ethyl-4-hydroxy-11-(1-hydroxypropyl)-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino-[1,2-b]quinolin-9-yl 1,4′-bipiperidine-1′-carboxylate

    Code: JCIRN-06
    CAS:
    Chemical Formula: C34H40N4O7
    Molecular Weight: 616.70
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan EP Impurity K ; (4S)-4-Ethyl-4-hydroxy-11-(1-hydroxypropyl)-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino-[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate is useful as reference Impurity standard
    Irinotecan EP Impurity K ; (4S)-4-Ethyl-4-hydroxy-11-(1-hydroxypropyl)-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino-[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate
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    Product Name : Irinotecan EP Impurity L ;Irinotecan HCl USP C D ;Irinotecan Enantiomer (EP) ;Irinotecan HCl R-Isomer ;(R)-9-[(1,4′-Bipiperidine)-1′-carbonyloxy]-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline hydrochloride

    Code:  JCIRN-05
    CAS: 
    Chemical Formula: C33H39ClN4O6
    Molecular Weight: 623.14
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan EP Impurity L ;Irinotecan HCl USP C D ;Irinotecan Enantiomer (EP) ;Irinotecan HCl R-Isomer ;(R)-9-[(1,4'-Bipiperidine)-1'-carbonyloxy]-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline hydrochloride  is useful as reference Impurity standard
    Irinotecan EP Impurity L ;Irinotecan HCl USP C D ;Irinotecan Enantiomer (EP) ;Irinotecan HCl R-Isomer  ;(R)-9-[(1,4'-Bipiperidine)-1'-carbonyloxy]-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline hydrochloride
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    Product Name : Irinotecan EP Impurity M ; 12-Hydroxy Irinotecan (EP) ;(4S)-4,11-Diethyl-4,12-dihydroxy-9-[(4-piperidinopiperidino) carbonyloxy]-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 185336-12-3

    Code: JCIRN-04
    CAS:  185336-12-3
    Chemical Formula:  C33H38N4O7
    Molecular Weight: 602.68
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan EP Impurity M ; 12-Hydroxy Irinotecan (EP) ;(4S)-4,11-Diethyl-4,12-dihydroxy-9-[(4-piperidinopiperidino) carbonyloxy]-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 185336-12-2   is useful as reference Impurity standard
    Irinotecan EP Impurity M ; 12-Hydroxy Irinotecan (EP) ;(4S)-4,11-Diethyl-4,12-dihydroxy-9-[(4-piperidinopiperidino) carbonyloxy]-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione  |  185336-12-3
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    Product Name : Irinotecan HCl Trihydrate ; (S)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin hydrochloride trihydrate ;[1,4’-Bipiperidine]-1’-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate | 136572-09-3

    Code: JCIRN-03
    CAS: 136572-09-3
    Chemical Formula: C33H45ClN4O9
    Molecular Weight: 677.18
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:  Irinotecan HCl Trihydrate ; (S)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin hydrochloride trihydrate ;[1,4’-Bipiperidine]-1’-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate | 136572-09-3  is useful as reference Impurity standard
    Irinotecan HCl Trihydrate ; (S)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin hydrochloride trihydrate ;[1,4’-Bipiperidine]-1’-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate  |  136572-09-3
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    Product Name : Irinotecan Hydroxy Keto Impurity ;10-Ethyl-2-methyl-3-propionyl-8-hydroxy-indolizino [1,2-b] quinoline-1-(11H)-one | 157770-58-6

    Code: JCIRN-02
    CAS:  157770-58-6
    Chemical Formula: C21H20N2O3
    Molecular Weight: 348.40
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Irinotecan Hydroxy Keto Impurity ;10-Ethyl-2-methyl-3-propionyl-8-hydroxy-indolizino [1,2-b] quinoline-1-(11H)-one | 157770-58-6   is useful as reference Impurity standard
    Irinotecan Hydroxy Keto Impurity ;10-Ethyl-2-methyl-3-propionyl-8-hydroxy-indolizino [1,2-b] quinoline-1-(11H)-one  |  157770-58-6
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    Product Name : Irinotecan Keto Impurity ;10-Ethyl-2-methyl-3-propionyl-8-[(4-piperidinopiperidino) carbonyloxy] indolizino [1,2-b] quinoline-1-(11H )-one

    Code: JCIRN-01
    CAS: NA
    Chemical Formula: C32H38N4O4
    Molecular Weight: 542.67
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Irinotecan Keto Impurity ;10-Ethyl-2-methyl-3-propionyl-8-[(4-piperidinopiperidino) carbonyloxy] indolizino [1,2-b] quinoline-1-(11H )-one  is useful as reference Impurity standard
    Irinotecan Keto Impurity ;10-Ethyl-2-methyl-3-propionyl-8-[(4-piperidinopiperidino) carbonyloxy] indolizino [1,2-b] quinoline-1-(11H )-one