Bortezomib

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Bortezomib API Reference standards  and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com

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    Product Name : Bortezomib Impurity 75; (3aS,4S,6S,7aR)-2-((S)-1-chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole; 85167-14-2

    Code: JCBRZ-22
    CAS: 85167-14-2
    Chemical Formula: C15H26BClO2
    Molecular Weight: 284.63
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib Impurity 75; (3aS,4S,6S,7aR)-2-((S)-1-chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole; 85167-14-2 is useful as reference Impurity standard.
    Bortezomib Impurity 75; (3aS,4S,6S,7aR)-2-((S)-1-chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole; 85167-14-2
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    Product Name : Bortezomib Impurity 10174-0629 ; ((R)-3-Methyl-1-((S)-3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acid

    Code: JCBRZ-21
    CAS: NA
    Chemical Formula: C28H34BN5O5
    Molecular Weight: 531.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib Impurity 10174-0629 ; ((R)-3-Methyl-1-((S)-3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acidis useful as reference Impurity standard.
    Bortezomib Impurity 10174-0629 ; ((R)-3-Methyl-1-((S)-3-phenyl-2-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acid
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    Product Name : Bortezomib Impurity 10174-0511 ; (R)-[3-methyl-1-(pyrazine-2-carboxamido)butyl]boronic acid

    Code: JCBRZ-20
    CAS: NA
    Chemical Formula: C10H16BN3O3
    Molecular Weight: 237.07
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib Impurity 10174-0511 ; (R)-[3-methyl-1-(pyrazine-2-carboxamido)butyl]boronic acidis useful as reference Impurity standard.
    Bortezomib Impurity 10174-0511 ; (R)-[3-methyl-1-(pyrazine-2-carboxamido)butyl]boronic acid
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    Product Name : N-(1[((R)-1-Hydroxy-3-Methylbutyl)Amino)-1-oxo-3-Phenylpropan-2-yl] Pyrazine-2-carboxamide; N-[(2RS)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide ; Bortezomib Hydroxy (1R, 2R)-Isomer ;

    Code: NA
    CAS: JCBRZ-19
    Chemical Formula: C19H24N4O3
    Molecular Weight: 356.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: N-(1[((R)-1-Hydroxy-3-Methylbutyl)Amino)-1-oxo-3-Phenylpropan-2-yl] Pyrazine-2-carboxamide; N-[(2RS)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide  ; Bortezomib Hydroxy (1R, 2R)-Isomer ;is useful as reference Impurity standard.
    N-(1[((R)-1-Hydroxy-3-Methylbutyl)Amino)-1-oxo-3-Phenylpropan-2-yl] Pyrazine-2-carboxamide; N-[(2RS)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide ; Bortezomib Hydroxy (1R, 2R)-Isomer ;
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    Product Name : Bortezomib USP Impurity L ; Bortezomib R-Hydroxyperoxide (USP) ; (R)-Hydroperoxy Des(boric Acid) Bortezomib ; N-((S)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide | 886979-78-8

    Code:  JCBRZ-18
    CAS: 886979-78-8
    Chemical Formula:  C19H24N4O4
    Molecular Weight: 372.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib USP Impurity L ; Bortezomib R-Hydroxyperoxide (USP) ; (R)-Hydroperoxy Des(boric Acid) Bortezomib ; N-((S)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide | 886979-78-8is useful as reference Impurity standard.
    Bortezomib USP Impurity L ; Bortezomib R-Hydroxyperoxide (USP) ; (R)-Hydroperoxy Des(boric Acid) Bortezomib ; N-((S)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide | 886979-78-8
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    Product Name : Bortezomib USP Impurity M ; Bortezomib S-Hydroxyperoxide (USP) ; (S)-Hydroperoxy Des(boric Acid) Bortezomib ; N-((S)-1-(((S)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide | 886979-81-3

    Code: JCBRZ-17
    CAS: 886979-81-3
    Chemical Formula: C19H24N4O4
    Molecular Weight: 372.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib USP Impurity M ; Bortezomib S-Hydroxyperoxide (USP) ; (S)-Hydroperoxy Des(boric Acid) Bortezomib ; N-((S)-1-(((S)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide | 886979-81-3is useful as reference Impurity standard.
    Bortezomib USP Impurity M ; Bortezomib S-Hydroxyperoxide (USP) ; (S)-Hydroperoxy Des(boric Acid) Bortezomib ; N-((S)-1-(((S)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide | 886979-81-3
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    Product Name : Bortezomib Impurity C|Bortezomib Pinanediol Impurity ;1R)-(S)-Pinanediol-N-(2-pyrazinylcarbonyl)-L-phenylalanine-L-leucine boronate ; (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate | 205393-22-2 

    Code: JCBRZ-16
    CAS: 205393-22-2
    Chemical Formula: C29H39BN4O4
    Molecular Weight: 518.46
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib Pinanediol Impurity ;1R)-(S)-Pinanediol-N-(2-pyrazinylcarbonyl)-L-phenylalanine-L-leucine boronate ; (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate | 205393-22-2 is useful as reference Impurity standard.
    Bortezomib Impurity C|Bortezomib Pinanediol Impurity ;1R)-(S)-Pinanediol-N-(2-pyrazinylcarbonyl)-L-phenylalanine-L-leucine boronate ;  (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate | 205393-22-2 
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    Product Name : Bortezomib N-Pentyl Impurity ; B-[(1R)-1-[[(2S)-1-Oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino] pentyl]boronic acid |1104011-35-9

     Code :  JCBRZ-15
     CAS :  1104011-35-9
     Formula :  C19H25BN4O4
     M.Wt :  384.24
     Category :  Bortezomib
    Bortezomib N-Pentyl Impurity ; B-[(1R)-1-[[(2S)-1-Oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino] pentyl]boronic acid |1104011-35-9
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    Product Name : Bortezomib N-Hexyl Impurity ; B-[(1R)-1-[[(2S)-1-Oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino] hexyl]boronic acid

    Code: JCBRZ-14
    CAS: 
    Chemical Formula: C20H27BN4O4
    Molecular Weight: 398.26
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib N-Hexyl Impurity ; B-[(1R)-1-[[(2S)-1-Oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino] hexyl]boronic acid is useful as reference Impurity standard.
    Bortezomib N-Hexyl Impurity ; B-[(1R)-1-[[(2S)-1-Oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino] hexyl]boronic acid
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    Product Name : Bortezomib Hydroxy Impurity (1S, 2S)-Isomer ; N-[(2S)-1-{[(1S)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide | 289472-81-7 

    Code: JCBRZ-13
    CAS: 289472-81-7
    Chemical Formula: C19H24N4O3
    Molecular Weight: 356.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib Hydroxy Impurity (1S, 2S)-Isomer ; N-[(2S)-1-{[(1S)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide | 289472-81-7 is useful as reference Impurity standard.
    Bortezomib Hydroxy Impurity (1S, 2S)-Isomer ; N-[(2S)-1-{[(1S)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide | 289472-81-7 
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    Product Name : Bortezomib Hydroxy Impurity (1S, 2R)-Isomer ; N-[(2R)-1-{[(1S)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide

    Code: JCBRZ-12
    CAS: NA
    Chemical Formula: C19H24N4O3
    Molecular Weight: 356.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib Hydroxy Impurity (1S, 2R)-Isomer ; N-[(2R)-1-{[(1S)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide is useful as reference Impurity standard.
    Bortezomib Hydroxy Impurity (1S, 2R)-Isomer ; N-[(2R)-1-{[(1S)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
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    Product Name : Bortezomib Hydroxy Impurity (1R, 2S)-Isomer ; N-[(2S)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide |  289472-78-2

    Code: JCBRZ-11
    CAS: 289472-78-2
    Chemical Formula: C19H24N4O3
    Molecular Weight:356.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib Hydroxy Impurity (1R, 2S)-Isomer ; N-[(2S)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide |  289472-78-2 is useful as reference Impurity standard.
    Bortezomib Hydroxy Impurity (1R, 2S)-Isomer ; N-[(2S)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide |  289472-78-2
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    Product Name : Bortezomib Hydroxy Impurity (1R, 2R)-Isomer ; N-[(2R)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide

    Code: JCBRZ-10
    CAS: 
    Chemical Formula: C19H24N4O3
    Molecular Weight: 356.42
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib Hydroxy Impurity (1R, 2R)-Isomer ; N-[(2R)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide is useful as reference Impurity standard.
    Bortezomib Hydroxy Impurity (1R, 2R)-Isomer ; N-[(2R)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
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    Product Name : Bortezomib Impurity F| Bortezomib Amide Impurity ; (2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanamide | 289472-80-6

    Code: JCBRZ-09
    CAS: 289472-80-6
    Chemical Formula: C14H14N4O2
    Molecular Weight: 270.29
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib Amide Impurity ; (2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanamide | 289472-80-6 is useful as reference Impurity standard.
    Bortezomib Impurity F| Bortezomib Amide Impurity ; (2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanamide | 289472-80-6
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    Product Name : Bortezomib Impurity B| Bortezomib Acid Methyl Ester ; (2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid methyl ester ;| 73058-37-4

    Code: JCBRZ-08
    CAS: 73058-37-4
    Chemical Formula: C15H15N3O3
    Molecular Weight: 285.3
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib Acid Methyl Ester ; (2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid methyl ester | 73058-37-4 is useful as reference Impurity standard.
    Bortezomib Impurity B| Bortezomib Acid Methyl Ester ; (2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid methyl ester ;| 73058-37-4
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    Product Name : Bortezomib Impurity A| Bortezomib Acid Impurity ;(2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid ; N-(2-Pyrazinyl carbonyl)-L-phenylalanine | 114457-94-2 

    Code: JCBRZ-07
    CAS: 114457-94-2
    Chemical Formula:C14H13N3O3
    Molecular Weight: 271.27
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib Acid Impurity ;(2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid ; N-(2-Pyrazinyl carbonyl)-L-phenylalanine | 114457-94-2 is useful as reference Impurity standard.
    Bortezomib Impurity A| Bortezomib Acid Impurity ;(2S)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid ; N-(2-Pyrazinyl carbonyl)-L-phenylalanine | 114457-94-2 
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    Product Name : Bortezomib ; (1R, 2S)-Bortezomib ; [(1R)-3-Methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  179324-69-7 

    Code: JCBRZ-06
    CAS: 179324-69-7
    Chemical Formula: C19H25BN4O4
    Molecular Weight: 384.24
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib ; (1R, 2S)-Bortezomib ; [(1R)-3-Methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  179324-69-7 is useful as reference Impurity standard.
    Bortezomib ; (1R, 2S)-Bortezomib ; [(1R)-3-Methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  179324-69-7 
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    Product Name : Bortezomib (2R)-Acid Methyl Ester ;  (2R)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid methyl ester

    Code: JCBRZ-05Bortezomib (2R)-Acid Methyl Ester ; (2R)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid methyl ester
    CAS: NA
    Chemical Formula: C15H15N3O3
    Molecular Weight:  285.3
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib (2R)-Acid Methyl Ester ;  (2R)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid methyl ester is useful as reference Impurity standard.
    Bortezomib (2R)-Acid Methyl Ester ;  (2R)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid methyl ester
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    Product Name : Bortezomib (2R)-Acid ; (2R)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid | 1608986-16-8

    Code: JCBRZ-04
    CAS: 1608986-16-8
    Chemical Formula: C14H13N3O3
    Molecular Weight: 271.27
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib (2R)-Acid ; (2R)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid | 1608986-16-8  is useful as reference Impurity standard.
    Bortezomib (2R)-Acid ; (2R)-3-Phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoic acid | 1608986-16-8
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    Product Name : Bortezomib Impurity E| Bortezomib (1S, 2S)-Isomer ;  [(1S)-3-Methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid | 1132709-14-8

    Code: JCBRZ-03
    CAS: 1132709-14-8
    Chemical Formula: C19H25BN4O4
    Molecular Weight: 384.24
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application:Bortezomib (1S, 2S)-Isomer ;  [(1S)-3-Methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid | 1132709-14-8 is useful as reference Impurity standard.
    Bortezomib Impurity E| Bortezomib (1S, 2S)-Isomer ;  [(1S)-3-Methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid | 1132709-14-8
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    Product Name : Bortezomib (1S, 2R)-Isomer ;[(1S)-3-Methyl-1-({(2R)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  1132709-16-0

    Code: JCBRZ-02
    CAS: 1132709-16-0
    Chemical Formula: C19H25BN4O4
    Molecular Weight: 384.24
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib (1S, 2R)-Isomer ;[(1S)-3-Methyl-1-({(2R)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  1132709-16-0is useful as reference Impurity standard.
    Bortezomib (1S, 2R)-Isomer  ;[(1S)-3-Methyl-1-({(2R)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  1132709-16-0
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    Product Name : Bortezomib Impurity D| Bortezomib (1R, 2R)-Isomer ;  [(1R)-3-Methyl-1-({(2R)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  1132709-15-9

    Code: JCBRZ-01
    CAS: 1132709-15-9
    Chemical Formula:C19H25BN4O4
    Molecular Weight: 384.24
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Bortezomib (1R, 2R)-Isomer ;  [(1R)-3-Methyl-1-({(2R)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  1132709-15-9 is useful as reference Impurity standard.
    Bortezomib Impurity D| Bortezomib (1R, 2R)-Isomer ;  [(1R)-3-Methyl-1-({(2R)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid |  1132709-15-9