Amlodipine

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Amlodipine API Reference standards  and its EP Impurities, USP Impurities, non pharmacopeial Impurities, listed below & also offered custom synthesis for unknown Impurities. If require any contact info@drjcrbio.com, sales@drjcrbio.com

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    Product Name : Amlodipine freebase; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine; 88150-42-9

    Code: JCAMD-15
    CAS: 88150-42-9
    Chemical Formula: C20H25ClN2O5
    Molecular Weight: 408.88
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine freebase; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine; 88150-42-9  is useful as reference Impurity standard.
    Amlodipine freebase; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine; 88150-42-9
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    Product Name : 2-[(2-Chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester; 400024-08-0

    Code: JCAMD-14
    CAS: 400024-08-0
    Chemical Formula: C₂₃H₂₀ClNO₆
    Molecular Weight: 441.86
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: 2-[(2-Chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester; 400024-08-0 is useful as reference Impurity standard.
    2-[(2-Chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester; 400024-08-0
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    Product Name : AMLO-DP1; 5-ethyl 7-methyl 6-(2-chlorophenyl)-8-methyl-3,4,6,8a-tetrahydro-2H-benzo[b][1,4]oxazine-5,7-dicarboxylate

    Code: JCAMD-13
    CAS: NA
    Chemical Formula: C20H22ClNO5
    Molecular Weight: 391.85
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: AMLO-DP1; 5-ethyl 7-methyl 6-(2-chlorophenyl)-8-methyl-3,4,6,8a-tetrahydro-2H-benzo[b][1,4]oxazine-5,7-dicarboxylateis useful as reference Impurity standard.
    AMLO-DP1; 5-ethyl 7-methyl 6-(2-chlorophenyl)-8-methyl-3,4,6,8a-tetrahydro-2H-benzo[b][1,4]oxazine-5,7-dicarboxylate
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    Product Name : Deschloro Amlodipine; 2-[(2-Aminoethoxy)methyl]-1,4-dihydro-6-methyl-4-phenyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester; 88150-52-1; 103069-33-6

    Code: JCAMD-12
    CAS: 88150-52-1; 103069-33-6
    Chemical Formula: C20H26N2O5
    Molecular Weight: 374.44
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Deschloro Amlodipine; 2-[(2-Aminoethoxy)methyl]-1,4-dihydro-6-methyl-4-phenyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester; 88150-52-1; 103069-33-6 is useful as reference Impurity standard.
    Deschloro Amlodipine; 2-[(2-Aminoethoxy)methyl]-1,4-dihydro-6-methyl-4-phenyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester; 88150-52-1; 103069-33-6
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    Product Name : Amlodipine para-Chloro Impurity; 4-chloro Amlodipine; 3-Ethyl 5-methyl Ester 2-[(2-Aminoethoxy)methyl]-4-(4-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid;90445-02-6

    Code: JCAMD-11
    CAS:  90445-02-6
    Chemical Formula: C20H25ClN2O5
    Molecular Weight: 408.88
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine para-Chloro Impurity; 4-chloro Amlodipine; 3-Ethyl 5-methyl Ester 2-[(2-Aminoethoxy)methyl]-4-(4-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid;90445-02-6 is useful as reference Impurity standard.
    Amlodipine para-Chloro Impurity; 4-chloro Amlodipine; 3-Ethyl 5-methyl Ester 2-[(2-Aminoethoxy)methyl]-4-(4-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid;90445-02-6
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    Product Name : Atorvastatin-Amlodipine Adduct ;3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-[[(3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl]amino]ethoxy]methyl]-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate | 425408-16-8

    Code: JCAMD-10
    CAS: 425408-16-8
    Chemical Formula: C53H58ClFN4O9
    Molecular Weight: 949.5
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Atorvastatin-Amlodipine Adduct ;3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-[[(3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl]amino]ethoxy]methyl]-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate | 425408-16-8 is useful as reference Impurity standard.
    Atorvastatin-Amlodipine Adduct ;3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-[[(3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl]amino]ethoxy]methyl]-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate  |  425408-16-8
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    Product Name : Amlodipine EP Impurity C ; Bis(aminoethoxy) Amlodipine|Ethyl methyl 2,6-bis[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | 721958-74-3

    Code: JCAMD-09
    CAS: 721958-74-3
    Chemical Formula: C22H30ClN3O6
    Molecular Weight: 467.94
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine EP Impurity C ; Bis(aminoethoxy) Amlodipine|Ethyl methyl 2,6-bis[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | 721958-74-3 is useful as reference Impurity standard.
    Amlodipine EP Impurity C ; Bis(aminoethoxy) Amlodipine|Ethyl methyl 2,6-bis[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  |  721958-74-3
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    Product Name : Amlodipine Besylate ;2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate | 111470-99-6

    Code: JCAMD-08
    CAS: 111470-99-6
    Chemical Formula: C26H31ClN2O8S
    Molecular Weight: 567.05
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine Besylate ;2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate | 111470-99-6 is useful as reference Impurity standard.
    Amlodipine Besylate ;2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate  |  111470-99-6
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    Product Name : Amlodipine EP Impurity H ; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[2-[(2-carboxybenzoyl) amino ethoxy)]methyl]-1,4-dihydropyridine-3,5-dicarboxylate | 318465-73-5

    Code: JCAMD-07
    CAS: 318465-73-5
    Chemical Formula: C28H29ClN2O8
    Molecular Weight: 556.99
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine EP Impurity H ; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[2-[(2-carboxybenzoyl) amino ethoxy)]methyl]-1,4-dihydropyridine-3,5-dicarboxylate | 318465-73-5 is useful as reference Impurity standard.
    Amlodipine EP Impurity H ; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[2-[(2-carboxybenzoyl) amino ethoxy)]methyl]-1,4-dihydropyridine-3,5-dicarboxylate  |  318465-73-5
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    Product Name : Amlodipine EP Impurity G ; 3-Methyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | 43067-01-2

    Code: JCAMD-06
    CAS: 43067-01-2
    Chemical Formula: C17H18ClN04
    Molecular Weight: 335.78
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature: Koukabi, Nadiya; Kolvari, Eskandar; Khazaei, Ardeshir; Zolfigol, Mohammad Ali; Shirmardi-Shaghasemi, Behzad; Khavasi, Hamid Reza [Chemical Communications, 2011, vol. 47, # 32, p. 9230 - 9232], Shaldam, Moataz Ahmed; El-Hamamsy, Mervat Hamed; Saleh, Dalia Osama; El-Moselhyb, Tarek Fathy [Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 4, p. 297 - 304], Koukabi, Nadiya; Kolvari, Eskandar; Zolfigol, Mohammad Ali; Khazaei, Ardeshir; Shaghasemi, Behzad Shirmardi; Fasahati, Behzad [Advanced Synthesis and Catalysis, 2012, vol. 354, # 10, p. 2001 - 2008]
    Application: Amlodipine EP Impurity G ; 3-Methyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | 43067-01-2 is useful as reference Impurity standard.
    Amlodipine EP Impurity G ; 3-Methyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate  |  43067-01-2
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    Product Name : Amlodipine EP Impurity F ; Amlodipine Dimethyl Ester ; 3-Methyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [(2-aminoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate | 140171-66-0

    Code: JCAMD-05
    CAS: 140171-66-0
    Chemical Formula: C17H18ClN04
    Molecular Weight: 335.78
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine EP Impurity F ; Amlodipine Dimethyl Ester;3-Methyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [(2-aminoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate | 140171-66-0 is useful as reference Impurity standard.
    Amlodipine EP Impurity F ; Amlodipine Dimethyl Ester ; 3-Methyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [(2-aminoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate  | 140171-66-0
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    Product Name : Amlodipine EP Impurity E ; Amlodipine Diethyl Ester ; 3-Ethyl 5-ethyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [(2-aminoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate | 140171-65-9

    Code: JCAMD-04
    CAS: 140171-65-9
    Chemical Formula: C21H27ClN2O5
    Molecular Weight: 422.9
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature: Alker, D; Arrowsmith, JE; Campbell, SF; Cross, PE [European Journal of Medicinal Chemistry, 1991, vol. 26, # 9, p. 907 - 913], ARTESIAN THERAPEUTICS, INC. WO2004/33444, 2004, A1 Location in patent: Page 30; 31-32
    Application:  Amlodipine EP Impurity E ; Amlodipine Diethyl Ester ; 3-Ethyl 5-ethyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [(2-aminoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate | 140171-65-9 is useful as reference Impurity standard.
    Amlodipine EP Impurity E ; Amlodipine Diethyl Ester ; 3-Ethyl 5-ethyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [(2-aminoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate  |  140171-65-9
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    Product Name : Amlodipine EP Impurity D ; Amlodipine USP Related Compound A|Dehydro Amlodipine Oxalate|3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-6-methylpyridine-3,5-dicarboxylate oxalate salt | 113994-41-5

    Code: JCAMD-03
    CAS: 113994-41-5
    Chemical Formula: C22H25ClN2O9
    Molecular Weight: 496.89
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine EP Impurity D ; Amlodipine USP Related Compound A; Dehydro Amlodipine Oxalate ; 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-6-methylpyridine-3,5-dicarboxylate oxalate salt | 113994-41-5 is useful as reference Impurity standard.
    Amlodipine EP Impurity D ; Amlodipine USP Related Compound A|Dehydro Amlodipine Oxalate|3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-6-methylpyridine-3,5-dicarboxylate oxalate salt  |  113994-41-5
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    Product Name : Amlodipine EP Impurity B ; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [[2-(methylcarbamoyl)benzoyl]amino]ethoxy]methyl]-1,4- dihydropyridine-3,5-dicarboxylate | 721958-72-1

    Code: JCAMD-02
    CAS: 721958-72-1
    Chemical Formula: C29H32ClN3O7
    Molecular Weight: 570.03
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine EP Impurity B ; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [[2-(methylcarbamoyl)benzoyl]amino]ethoxy]methyl]-1,4- dihydropyridine-3,5-dicarboxylate | 721958-72-1 is useful as reference Impurity standard.
    Amlodipine EP Impurity B ; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[[2- [[2-(methylcarbamoyl)benzoyl]amino]ethoxy]methyl]-1,4- dihydropyridine-3,5-dicarboxylate  |  721958-72-1
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    Product Name : Amlodipine EP Impurity A ; Phthalimido Amlodipine ; 3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | 88150-62-3

    Code: JCAMD-01
    CAS: 88150-62-3
    Chemical Formula:C28H27ClN2O7
    Molecular Weight: 538.98
    Category: Reference Standards/API Drug Metabolites/EP Impurities/USP Impurities
    Literature:
    Application: Amlodipine EP Impurity A ; Phthalimido Amlodipine; 3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | 88150-62-3 is useful as reference Impurity standard.
    Amlodipine EP Impurity A ; Phthalimido Amlodipine ; 3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate  |  88150-62-3