ABOUT US

DR. JCR BIO-SCIENCES PRIVATE LIMITED, was founded in 2012 by Dr. Reddy, JC after huge experience in organic synthesis.The Laboratory represents a diverse talented team of dedicated professionals that have extensive experienced in medicinal chemistry basic organic synthesis, process chemistry and academic side.

REACTION

We are growing to ramp up fast track solutions for projects and a capable CRO / CMO provider. We have a broad portfolio of laboratory and research manufacturing services ranging from discovery chemistry to high quality manufacturing of Impurities/Metabolites/Intermediate API’s and Research chemicals for Fast track discoveries as per their regulatory requirements

We specialize in a full spectrum of chemical research services such as:

  • Custom synthesis of various scaffolds building blocks
  • Reference compounds and custom reagent development
  • Contract research and manufacture services
  • Intermediates for  API services
  • Import and Export of products partnering
  • We routinely carry out multi-step sequences to prepare mg to Kg quantities.

Our specialities in handling procedures include:

  • Pressure, hygroscopic and air-sensitive reactions/ reagents.
  • Sealed tube, steel bomb, microwave and ultrasonication reactions.
  • Oxidation, reduction, cyclisation, condensation, halogenations, protection/deprotection of amines, alcohols, phenols and carbonyl compounds etc.

Application of various named reactions:
Appel Reaction, Aldol condensation, Buchwald-Hartwig cross coupling reaction, Cross metathesis (Grubbs Catalyst), CBS reduction, Clemmensen reduction, Diazomethane reaction, Epoxidation, Fischer Esterification, Friedel-Crafts Acylation, Fries Rearrangement, Grignard Reaction, Heck coupling, Hell-Volhard-Zelinisky reaction, Michael addition, Mitsunobu Reaction, Negishi Coupling, Prilezhaev reaction, Knoevenagel condensation, Kumuda coupling, Reformatsky reaction, Rodenson reaction (Mannich reaction), racemisation, Sandmeyer Reaction, Sonogashira Coupling, Stille coupling, Swern oxidation, Suzuki coupling, Wolff-Kishner reduction, Witting reaction, Weinreb-Ketone Synthesis, Williamson synthesis, Wohl-Ziegler Reaction, Vilsmeier Reaction etc.

The Team specialize not only above reactions.

Experience in epimerization of diasteriomers and further enatiomeric resolutions via salt formation, enzymatic hydrolysis and using chiral auxiliary etc.

All types of metal catalyst and ligands.

Reduction Reagents:
LiAlH4, NaBH4, Na(CN)BH3, Na(AcO)3BH, DIBAL-H, BH3-DMS, Et3SiH, Tributyltin hydride, Stannous chloride, PtO2, Pd/C, Pd(OH)2/C (10%), Zn/ acetic acid, (Na, Mg, Li) metals, chiral oxazaborolidine, Sodium dithionate and ( L, Na, k) -Selectride etc.

Oxidation Reagents:
KMnO4,PCC, PDC, Chromium trioxide, Selenium dioxide, Swern oxidation, MnO2, KMnO4, DDQ, hydrogen peroxide, MCPBA, Oxone, IBX, DMP, 1,3-Dibromo-5,5-Dimethylhydantoin, NBS, NCS and  NIS., etc.

Coupling Reagents:
CDI, DCC, T3P, EDCI, HOBt, BOP, PyBOP, HATU, HBTU, TATU, HBTU, TBTU, T3P, DEAD, DIAD, Mukaiyama coupling reagent etc.

Other reagents:
n-BuLi, Sec-BuLi, t-BuLi, LDA, (Li, Na, K) HMDS, Red P, PCl5, BBr3, PBr3, CBr4, ter-butyldimethysilylchloride, tributyltin chloride, triphosgene,methane sulfonylchloride, Lewis acids (AlCl3, BF3 –etherate, TiCl4, SnCl4) and  (Na, K) hydride, 9-BBN, Tebbe’s reagent etc.

The above all reactions and reagents use in safe condition, and contribute our prestigious customers to support their discoveries.

Our customers range from small biotech firms to leading pharmaceutical corporations. We can work with your process, or develop a new process to simplify and improve difficult and expensive synthetic routes.
FTE service is also available.